GO:0072559 cellular_component NLRP3 inflammasome complex
| PAG Title | GO:0072559 cellular_component NLRP3 inflammasome complex |
| PAG ID | TAX030058 |
| Type | A |
| Source Link |  GOA |
| Publication Reference | NA |
| PAG Description | A protein complex that consists of three components, NLRP3 (NALP3), PYCARD and caspase-1. It is activated upon exposure to whole pathogens, as well as a number of structurally diverse pathogen- and danger-associated molecular patterns (PAMPs and DAMPs) and environmental irritants. Whole pathogens demonstrated to activate the NLRP3 inflammasome complex include the fungi Candida albicans and Saccharomyces cerevisiae, bacteria that produce pore-forming toxins, including Listeria monocytogenes and Staphylococcus aureus, and viruses such as Sendai virus, adenovirus, and influenza virus. |
| Species | Homo sapiens |
| Quality Metric Scores | nCoCo Score: 505 |
| Information Content | Rich |
| Other IDs | GO:0072559 |
| Base PAG ID | TAX030058 |
| Human Phenotyte Annotation | |
| Curator | PAGER curation team |
| Curator Contact | PAGER-contact@googlegroups.com |
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